Jimmy Livingston was born without immunities and has spent his entire life confined inside a plastic bubble room. Enter Chloe, the girl next door, who becomes his friend and steals his heart. When she leaves town to get married, Jimmy travels cross-country in a homemade bubble suit in order to stop the wedding and finally tell her how he feels. Along the laugh-filled journey he deals with a crazy cult, a biker gang, a dead cow, and a controlling mother who will stop at nothing to get him back in the bubble.