In a small San Francisco apartment in the 1990s, Meryl and Ana Sofia, a lesbian couple, attempt to conceive a child through in-vitro fertilization while managing Meryl's bipolar disorder. Two decades later, in the same apartment, their daughter Robyn and her roommate Hadley are forced to navigate their friendship through Robyn’s cancer treatment. As they struggle to take control of their lives, all four come to experience the unique weight and loss of female friendship. A wrenching, tender portrait of characters who are complicated the way real women are, 'delicacy of a puffin heart' considers what it means to love someone honestly even when they are incapable of telling the truth.